Local anaesthetics and adjuvants - future developments
نویسندگان
چکیده
منابع مشابه
Adjuvants to local anesthetics: Current understanding and future trends
Although beneficial in acute and chronic pain management, the use of local anaesthetics is limited by its duration of action and the dose dependent adverse effects on the cardiac and central nervous system. Adjuvants or additives are often used with local anaesthetics for its synergistic effect by prolonging the duration of sensory-motor block and limiting the cumulative dose requirement of loc...
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almost directly after the Mental Deficiency Act came into force in 1914. One of their main objects was the co-ordination of all public and voluntary work undertaken for defectives in their own homes, throughout the area, covered by a Local Authority under the Mental Deficiency Act, i.e., a County or County Borough. The Constitution of these Associations varies according to Local conditions but ...
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The problem with pure recombinant or synthetic antigens used in modern day vaccines is that they are generally far less immunogenic than older style live or killed whole organism vaccines. This has created a major need for improved and more powerful adjuvants for use in these vaccines. With few exceptions, alum remains the sole adjuvant approved for human use in the majority of countries worldw...
متن کاملBeyond antigens and adjuvants: formulating future vaccines.
The need to optimize vaccine potency while minimizing toxicity in healthy recipients has motivated studies of the formulation of vaccines to control how, when, and where antigens and adjuvants encounter immune cells and other cells/tissues following administration. An effective subunit vaccine must traffic to lymph nodes (LNs), activate both the innate and adaptive arms of the immune system, an...
متن کاملA comparison of local anaesthetics for venepuncture.
AIM To compare the effectiveness of EMLA cream and Ametop gel in providing analgesia for venous cannulation. METHODS Single blind study in 120 children. RESULTS Both anaesthetic agents produced adequate analgesia. However, Ametop gel was more effective, with a statistically significant difference in the pain scores of the two groups (p < 0.05).
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ژورنال
عنوان ژورنال: Anaesthesia
سال: 2010
ISSN: 0003-2409,1365-2044
DOI: 10.1111/j.1365-2044.2009.06201.x